With most clinical trials delayed by recruitment shortfalls, TrialWire embeds AI-driven patient enrollment from study start-up - keeping trials on pace so they never reach rescue. Activation in under 24 hours, on a success-based fee model.

TrialWire, the AI- and algorithm-powered patient recruitment and enrollment platform, is making the case for rescue prevention: keeping recruitment on pace from the very start of a study so a trial never falls into an enrollment crisis. Its Platform switches on intelligent recruitment at site activation and sustains it throughout enrollment, closing gaps before they widen into the kind of shortfall that forces a costly rescue.

By the time a trial is flagged as behind, options are expensive and time is short. Rescue prevention reframes recruitment as a decision made at start-up, not a scramble made under pressure.

The problem: recruitment is still the leading cause of trial delay

The enrollment challenge behind most trial timelines is well documented: more than 80% of clinical trials are delayed by patient recruitment issues, roughly 30% of research sites fail to meet their enrollment goals, and around 10% of sites never enroll a single patient. Each missed target extends timelines, inflates budgets, and pushes back the moment a promising therapy reaches patients - and the further a trial slips, the harder and more expensive it is to recover.

The solution: prevent the crisis instead of reacting

TrialWire runs continuous, AI-driven recruitment that keeps enrollment on pace from the outset. Switched on from site activation, it identifies and pre-screens motivated people already searching for health information online, then delivers site-ready candidates with meaningful context - advancing quality over raw referral volume so coordinators aren’t buried in unqualified leads. Because enrollment stays ahead of the curve, sponsors avoid the slow slide toward a rescue in the first place.

How it works

• Under-24-hour activation - recruitment can begin within a day of study configuration

• AI-Match precision screening - advanced AI and algorithms find and pre-screen suitable candidates in real time.

• Success-based pricing - a risk-share, pay-per-enrolled-patient model that aligns cost with outcomes rather than referral counts.

• Built-in compliance and security - full HIPAA and GDPR compliance, role-based access, and secure coordinator-to-patient communication, all purpose-built on Salesforce Health Cloud.

The platform supports single-country, regional, global, and hybrid decentralized trials across multiple languages, with a particular strength in historically difficult areas such as oncology, rare diseases, and CNS.

“The best trial rescue is the one you never need,” said Susan Fitzpatrick-Napier, CEO and Founder of TrialWire. “Recruitment is the single biggest reason trials run late, yet it’s still too often treated as an emergency to be handled after the damage is done. TrialWire flips that: by keeping enrollment on pace from start-up, sponsors prevent the crisis instead of paying to fix it - and life-changing treatments reach patients sooner.”

About TrialWire

TrialWire is an AI- and algorithm-powered clinical trial patient recruitment and enrollment platform, purpose-built on Salesforce Health Cloud to deliver best-in-class data and security. The platform activates in under 24 hours, identifies and pre-screens motivated participants in real time, and connects them to sites through a secure, compliant environment - all on a success-based fee model. TrialWire keeps studies on pace to prevent an enrollment crisis, and it has been recognized across the industry for excellence in patient recruitment and retention. TrialWire operates from offices in San Francisco, Sydney, Singapore, and Paris.

Learn more at www.trialwire.ai.